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Multimode Fiber Optics Inc
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NEWDOON Inc
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NEWDOON Inc
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Precision Fiber Products Inc
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Multimode Fiber Optics Inc
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MKS Instruments
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Image Search Results
Journal: Frontiers in Neuroengineering
Article Title: Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter
doi: 10.3389/fneng.2014.00040
Figure Lengend Snippet: NeuroRighter software and hardware for calibration, optical stimulation, and recording. NeuroRighter’s main application window enables real-time isolation of single units (A) and local field potentials (LFP; B ) from multielectrode arrays, with real-time visualization of the electrophysiologic response to optical stimulus ( B , magenta arrow). (C) A comparison between the mean (dot) and SD (error bars) normalized output of a 473 nm blue DPSS Laser (Shanghai Dream Laser; red) and 465 nm blue LED (Plexon, Inc.) output (black). Note the high variance associated with the laser output as compared to the LED (present for the LED but smaller than the data point marker), and the non-linear nature of the laser output. (D) Plexon LED Driver, 465 nm blue LED module, and 200 μm 0.67 NA armored patch fiber cable. (E) Custom-made optical ferrules utilizing 200 μm diameter 0.37 NA fiber optic. (F) 3D-printed Intensity Chamber design (top) and fabricated with accompanying photodiode (bottom). Custom-designed and fabricated ferrules (E) plug into the chamber ( F , bottom right) which overlays the S121C detector ( F , bottom left). (G) Labview-based program for Automated Ferrule Intensity Calibration (C) . (H) A 3D-printed implantation post has multiple modules to enable ferrule implantation alone ( H , bottom right) or coupled to an array (H , top right, J) . (I) TDT 16-channel MEA, which was implanted in the dorsal hippocampus targeting CA1 and CA3 simultaneously. (J) A H-style NeuroNexus 16 channel shank array was manually glued to a calibrated ferrule (K) , enabling simultaneous stimulation, and recording from the same target site.
Article Snippet: To stimulate awake and behaving animals, calibrated ferrules were connected via
Techniques: Software, Isolation, Marker